* co-first author; # co-corresponding author. Current and past lab members’ names are in bold.
In the pipeline
Gupta et al. (including Jaeyun Sung#) and Erin E. Longbrake#. “Alterations in Gut Microbiome-Host Relationships Induced by Immune Perturbation with B cell depletion in Patients with Multiple Sclerosis”. submitted.
Hur et al. (including Vinod K. Gupta) and Jaeyun Sung. “Integrative Multi-omics Phenotyping in Blood Reveals Biomolecular Signatures Predictive of ACPA-negative Rheumatoid Arthritis”. submitted.
Cunningham* and Hur* et al. (including Vinod K. Gupta) and Jaeyun Sung. “Plasma Proteome Profiling in Giant Cell Arteritis”. in revision at Annals of the Rheumatic Diseases.
Zhang et al. (including Kevin Cunningham and Jaeyun Sung), and Jordan Miller. “Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis“. in revision at Circulation.
Chang* and Gupta* et al., (including Benjamin Hur, Sergio Cobo-López, and Kevin Y. Cunningham) and Jaeyun Sung. “Gut Microbiome Wellness Index 2 for Enhanced Health Status Prediction from Gut Microbiome Taxonomic Profiles”. in revision at Nature Communications. [bioRxiv]
2024
Anthony D. Umpierre, Bohan Li, Katayoun Ayasoufi, Shunyi Zhao, Manling Xie, Grace Thyen, Benjamin Hur, Jiaying Zheng, Yue Liang, Zhaofa Wu, Xinzhu Yu, Jaeyun Sung, Aaron J. Johnson, Yulong Li, and Long-Jun Wu. “Microglial P2Y6 Calcium Signaling Promotes Phagocytosis and Shapes Neuroimmune Responses in Epileptogenesis”. Neuron (2024). [html][pdf]
Vinod K. Gupta*, Sanu Rajendraprasad*, Mahmut Ozkan, Dhanya Ramachandran, Sumera Ahmad, Johan S. Bakken, Krzysztof Laudanski, Ognjen Gajic, Brent Bauer, Simon Zec, David W. Freeman, Sahil Khanna, Aditya Shah, Joseph H. Skalski, Jaeyun Sung# and Lioudmila V. Karnatovskaia#. “Safety, Feasibility, and Impact on the Gut Microbiome of Kefir Administration in Critically Ill Adults”. BMC Medicine (2024). [html][pdf]
Humza Haroon, Ada Man-Choi Ho, Vinod K. Gupta, Surendra Dasar, Carl M. Sellgren, Simon Cervenka, Göran Engberg, Feride Eren, Sophie Erhardt, Jaeyun Sung, and Doo-Sup Choi. “Cerebrospinal Fluid Proteomic Signatures are Associated with Symptom Severity of First-episode Psychosis”. Journal of Psychiatric Research (2024). [html][pdf]
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Joseph Skalski, Johan S. Bakken, and Lioudmila V. Karnatovskaia. “The Human Gut Microbiome in Critical Illness: Disruptions, Consequences, and Therapeutic Frontiers” (review). Journal of Critical Care (2024). [html][pdf]
2023
Dong Hyeon Lee, Hyunbin Seong, Daniel Chang, Vinod K. Gupta, Jiseung Kim, Seongwon Cheon, Geonhee Kim, Jaeyun Sung#, and Nam Soo Han#. “Evaluating the Prebiotic Effect of Oligosaccharides on Gut Microbiome Wellness Using in vitro Fecal Fermentation”. NPJ Science of Food (2023). [html][pdf]
Kevin Y. Cunningham, Benjamin Hur, Vinod K. Gupta, Courtney A. Arment, Kerry A. Wright, Thomas G. Mason, Lynne S. Peterson, Delamo I. Bekele, Daniel E. Schaffer, Marissa L. Bailey, Kara E. Delger, Cynthia S. Crowson, Elena Myasoedova, Hu Zeng, Moses Rodriguez, Cornelia M. Weyand, John M. Davis III, and Jaeyun Sung. “Patients with ACPA-positive and ACPA-negative Rheumatoid Arthritis Show Different Serological Autoantibody Repertoires and Autoantibody Associations with Disease Activity”. Scientific Reports (2023). [html][pdf]
Daniel Chang, Vinod K. Gupta, Benjamin Hur, Kevin Y. Cunningham, and Jaeyun Sung. “GMWI-webtool: A User-friendly Browser Application for Assessing Health through Metagenomic Gut Microbiome Profiling”. Bioinformatics (2023). [html][pdf]
2022
Vinod K. Gupta, Utpal Bakshi, Daniel Chang, Aileen R. Lee, John M. Davis III, Sriram Chandrasekaran, Yong-Su Jin, Michael F. Freeman, and Jaeyun Sung. “TaxiBGC: a Taxonomy-guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters in Metagenomes”. mSystems (2022). [html][pdf][blog]
Alfredo Oliveros, Ki-Hyun Yoo, Mohammad Abdur Rashid, Ana Corujo-Ramirez, Benjamin Hur, Jaeyun Sung, Yuanhang Liu, John R. Hawse, Doo-Sup Choi, Detlev Boison, and Mi-Hyeon Jang. “Adenosine A2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function”. PNAS (2022). [html][pdf]
Sergio Cobo-López, Vinod K. Gupta, Jaeyun Sung#, Roger Guimerà#, and Marta Sales-Pardo#. “Stochastic Block Models Reveal a Robust Nested Pattern in Healthy Human Gut Microbiomes”. PNAS Nexus (2022). [html][pdf]
Benjamin Hur, Matthew J. Koster, Jin Sung Jang, Cornelia M. Weyand, Kenneth J. Warrington, and Jaeyun Sung. “Global Transcriptomic Profiling Identifies Differential Gene Expression Signatures between Inflammatory and Non-inflammatory Aortic Aneurysms”. Arthritis & Rheumatology (2022). [html][pdf]
Chan Hyuk Park, Changjin Hong, A-reum Lee, Jaeyun Sung#, Tae Hyun Hwang#. “Multi-omics Reveals Microbiome, Host Gene Expression, and Immune Landscape in Gastric Carcinogenesis”. iScience (Cell Press) (2022). [html][pdf]
Minsuk Kim, Jaeyun Sung, and Nicholas Chia. “Resource-allocation Constraint Governs Structure and Function of Microbial Communities in Metabolic Modeling”. Metabolic Engineering (2022). [html][pdf]
2021
Vinod K. Gupta, Kevin Y. Cunningham, Utpal Bakshi, Benjamin Hur, Harvey Huang, Kenneth J. Warrington, Veena Taneja, Elena Myasoedova, John M. Davis III, and Jaeyun Sung. “Gut Microbial Determinants of Clinically Important Improvement in Patients with Rheumatoid Arthritis”. Genome Medicine (2021). [html][pdf][blog][MDedge][CBS News]
Benjamin Hur, Vinod K. Gupta, Harvey Huang, Kerry A. Wright, Kenneth J. Warrington, Veena Taneja, John M. Davis III, and Jaeyun Sung. “Plasma Metabolomic Profiling in Patients with Rheumatoid Arthritis Identifies Biochemical Features Predictive of Quantitative Disease Activity”. Arthritis Research & Therapy (2021). [html] [pdf] [blog]
2020
Elizabeth Ann L. Enninga*, Jin Sung Jang*, Benjamin Hur, Erica L. Johnson, Myra J. Wick, Jaeyun Sung, and Rana Chakraborty. “Maternal Obesity is Associated with Phenotypic Alterations in Fetal Immune Cells By Single-cell Mass Cytometry”. American Journal of Reproductive Immunology (2020). [html] [pdf]
Vinod K. Gupta, Minsuk Kim, Utpal Bakshi, Kevin Y. Cunningham, John M. Davis III, Konstantinos N. Lazaridis, Heidi Nelson, Nicholas Chia, and Jaeyun Sung. “A Predictive Index for Health Status Using Species-level Gut Microbiome Profiling”. Nature Communications (2020). [html] [pdf] [talk]
Ranked #17 of the Top 50 2020 Life and Biological Sciences Articles in Nature Communications
Jin Sung Jang, Brian Juran, Kevin Y. Cunningham, Vinod K. Gupta, Young Min Son, Ju Dong Yang, Ahmad H. Ali, Elizabeth Ann L. Enninga, Jaeyun Sung#, and Konstantinos N. Lazaridis#. “Single-Cell Mass Cytometry on Peripheral Blood Identifies Immune Cell Subsets Associated with Primary Biliary Cholangitis”. Scientific Reports (2020) [html] [pdf]
Roktaek Lim, Josephine Jill T. Cabatbat, Haneul Kim, Thomas L. P. Martin, Seunghyeon Kim, Jaeyun Sung, Cheol-Min Ghim, and Pan-Jun Kim. “Large-scale Metabolic Interaction Network of the Mouse and Human Gut Microbiota”. Scientific Data (2020) [html] [pdf]
Minsuk Kim*, Emily Vogtmann*, David A. Ahlquist, Mary E. Devens, John B. Kisiel, William R. Taylor, Vanessa L. Hale, Jaeyun Sung, Nicholas Chia#, Rashmi Sinha#, Jun Chen. “Fecal Metabolomic Signatures in Colorectal Adenoma Patients are Associated with Gut microbiota and Early Events of Colorectal Cancer Pathogenesis”. mBio (2020) [html] [pdf]
2019
Dana M. Walsh*, Alexis N. Hokenstad*, Jun Chen, Jaeyun Sung, Gregory D. Jenkins, Nicholas Chia, Heidi Nelson, Andrea Mariani#, Marina R. S. Walther-Antonio#. “Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome)”. Scientific Reports (2019) [html] [pdf]
2018
Vanessa L. Hale, Patricio Jeraldo, Jun Chen, Michael Mundy, Janet Yao, Sambhawa Priya, Gary Keeney, Kelly Lyke, Jason Ridlon, Bryan A. White, Amy J. French, Stephen N. Thibodeau, Christian Diener, Osbaldo Resendis-Antonio, Jaime Granse, Tumpa Dutta, Xuan-Mai Petterson, Jaeyun Sung, Ran Blekhman, Lisa Boardman, David Larson, Heidi Nelson, and Nicholas Chia. “Distinct Microbes, Metabolites, and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers”, Genome Medicine (2018) [html] [pdf]
Pamela S. Tietz-Bogert*, Minsuk Kim*, Angela Cheung, James H. Tabibian, Madhumitha Nandakumar, Elizabeth Halvorsen, Julie K. Heimbach, Charles B. Rosen, Konstantinos N. Lazaridis, Nicholas F. LaRusso, Jaeyun Sung#, and Steven P. O’Hara#. “Metabolomic Profiling of Portal Serum and Bile Reveals Metabolic Signatures in Patients with Primary Sclerosing Cholangitis”, International Journal of Molecular Sciences (2018) [html] [pdf]
———— with previous affiliations ————
2018
Christopher S. Smillie, Jenny Sauk, Dirk Gevers, Jonathan Friedman, Jaeyun Sung, Ilan Youngster, Elizabeth L. Hohmann, Christopher Staley, Alexander Khoruts, Michael J. Sadowsky, Jessica R. Allegretti, Mark B. Smith, Ramnik J. Xavier, and Eric J. Alm. “Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation”, Cell Host and Microbe (2018) [html] [pdf]
2017
Jaeyun Sung, Seunghyeon Kim, Josephine Jill T. Cabatbat, SungHo Jang, Yong-Su Jin, Gyoo Yeol Jung, Nicholas Chia, and Pan-Jun Kim. “Global Metabolic Interaction Network of the Human Gut Microbiota for Context-specific Community-scale Analysis”, Nature Communications (2017) [html] [pdf]
2016
Jaeyun Sung, Vanessa Hale, Annette C. Merkel, Vanessa Hale, Pan-Jun Kim, and Nicholas Chia. “Metabolic Modeling with Big Data and the Gut Microbiome”, Applied and Translational Genomics (2016) [html] [pdf]
Jun-Seob Kim, Da-Hyeong Cho, Paul Heo, Suk-Chae Jung, Myungseo Park, Eun Joong Oh, Jaeyun Sung, Pan-Jun Kim, Sukchan Lee, Dae-Hee Lee, Sarah Lee, Choong Hwan Lee, Dongwoo Shin, Yong-Su Jin, and Dae-Hyuk Kweon. “Fumarate-mediated Persistence of Escherichia coli to Antibiotics”, Antimicrobial Agents and Chemotherapy (2016) [html] [pdf]
2015
Seunghyeon Kim, Jaeyun Sung, Mathias Foo, Yong-Su Jin, and Pan-Jun Kim. “Uncovering the Nutritional Landscape of Food”, PLoS ONE (2015) [html] [pdf]
2014
Shuyi Ma, Jaeyun Sung, Andrew T. Magis, Yuliang Wang, Donald Geman, Nathan D. Price. “Measuring the Effect of Inter-study Variability on Learning Molecular Signatures”, PLoS ONE (2014) [html] [pdf]
Christopher Lausted, Inyoul Lee, Yong Zhou, Shizhen Qin, Jaeyun Sung, Nathan D. Price, Leroy Hood, and Kai Wang. “Systems Approach to Neurodegenerative Disease Biomarker Discovery”, Annual Reviews of Pharmacology and Toxicology (2014) [html] [pdf]
2013
Jaeyun Sung, Pan-Jun Kim, Shuyi Ma, Cory C. Funk, Andrew T. Magis, Yuliang Wang, Leroy Hood, Donald Geman, and Nathan D. Price. “Multi-study Integration of Brain Cancer Transcriptomes Reveals Organ-Level Molecular Signatures”, PLoS Computational Biology (2013) [html] [pdf]
2012
Jaeyun Sung, Yuliang Wang, Sriram Chandrasekaran, Daniella M. Witten, and Nathan D. Price. “Molecular Signatures from Omics Data: from Chaos to Consensus”, Biotechnology Journal (2012) [html] [pdf]
2010
James A. Eddy, Jaeyun Sung, Donald Geman, and Nathan D. Price. “Gene-pair Relative Expression Analysis for Cancer Diagnosis and Prognosis”, Technology in Cancer Research and Treatment (2010) [html] [pdf]
MAQC Consortium (including Jaeyun Sung). “The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models”, Nature Biotechnology (2010) [html] [pdf]
2009
Jaeyun Sung, Paul W. Barone, Hyunjoon Kong, and Michael S. Strano. “Sequential Delivery of Dexamethasone and VEGF to Control Local Tissue Response for Carbon Nanotube Fluorescence Based Micro-capillary Implantable Sensors”, Biomaterials (2009) [html] [pdf]
Patents
Jaeyun Sung, John M. Davis III, and Benjamin Hur. “Methods and Materials for Assessing and Treating Arthritis”. Patent application submitted to USPTO (#17/899,272).
Jaeyun Sung and Vinod Gupta. “Assessing Gut Health using Metagenome Data”. Patent application submitted to USPTO (#17/295,098).
Jaeyun Sung and Vinod Gupta. “Assessing Gut Health using Metagenome Data”. WIPO Patent #WO2021102293A1.
Nathan D. Price, Leroy Hood, Jaeyun Sung, and Donald Geman. “Detection of Brain Cancer Types”. US Patent #20150252429.
Nathan D. Price, Leroy Hood, Jaeyun Sung, and Donald Geman. “Detection of Brain Cancer Types”. WIPO Patent #WO/2014/071082 A2.